Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
"Everywhere I go business owners are seeing an increase in demand," said Gus Faucher, senior economist at PNC Financial Services. "Businesses will have to raise wages to attract or maintain workers."
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Purchase products like magazine racks, shelves, and desk organizers that will keep your supplies and resources in order and close-at-hand. We love the File File, $24.95, at CB2.com (pictured above).
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Paul was a pretty undersized guard back in high school, which is probably why he's developed such a "me against the world" mentality. CP3 is one of the grittiest and toughest players in the NBA, and he has to be because he sure isn't one of the biggest.
The artefact which has a flat base was found inside an ancient tomb in the Xuyi County in western Jiangsu in 2009. It has been kept at the Nanjing Museum the capital of Jiangsu Province.
以丹麦为例，如今，88%的丹麦人口都是白人——这样的多数地位很难动摇。但在1980年，也就是上一代人的时候，丹麦有97%的人口是白人。反移民的丹麦人民党(Danish People’s Party)现在是丹麦议会中的第二大党。在德国，从2011年到2015年间，非本土出生人口激增了大约75%，反移民的民粹政党德国另类选择党(Alternative for Germany)如今获得了破纪录的支持率。
Trends and targets in antiviral phototherapy
In 2008, China's government added an entry to the list of conditions classified as mental illnesses: "Internet addiction." According to numerous reports in state-run media, China's young people were spending too much time in Internet cafes, ignoring family or work to play online games into the wee hours, sometimes neglecting to eat, drink, or sleep, and endangering their own health.
Bottoms Up is the revolutionary new way to serve beer. The Bottoms Up system saves time, eliminates waste and awes customers!
Nothing else matters, not even basic astronomy.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Lighting is key when it comes to getting work done. Instead of investing in your typical, boring college dorm room desk lamp, pick something with a prettier design. Check out vintage stores for one-of-a-kind table lamps or keep it cheap with the Tiffany Table Lamp, $99.99, at Target.com.
Novel biosensing methodologies for ultrasensitive detection of viruses
NeXT 电脑公司总裁兼CEO史蒂夫乔布斯在向公众展示他的新一代NeXT 工作站（此时乔布斯已经离开苹果创办了皮克斯动画和NeXT 电脑公司），1990年9月18日，旧金山
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
There was no indication of the identity of the kidnappers or their motive.
ACE2 as a potential therapeutic target for pandemic COVID-19
The most popular surgical procedures include double eyelid surgery - which reduces excess skin in the upper eyelid to make the eyes appear bigger, lipoplasty - which uses high-frequency sound waves to eliminate fat - and nose jobs.
HOW MUCH: $2,050,000
Diagnostic technologies for COVID-19: a review
Morgan Stanley CEO James Gorman will do an about-face on the bank's 'lower risk' corporate strategy.
The continued, albeit slower growth in prices tracks with recent data showing real estate investment ticked upward in October and sales had registered barely any negative impact from the new restrictions.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
On Saturday night they sang Stars from Les Miserables, the song performed the character Javert in the long-running musical.
We had everything before us, we had nothing before us…
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Maddie has now appeared in three of Sia's videos - Chandelier, Elastic Heart and Big Girls Cry.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
At least two Harvard professors, however, questioned the decision to withdraw the offers. Alan Dershowitz, an emeritus professor at Harvard Law School, told the Guardian that losing admission to Harvard was a "draconian punishment" for "very bad taste jokes that students were sending to each other".
Antiviral drug discovery: broad-spectrum drugs from nature
Two arrests have been made in connection to the shooting death of 14-year-old Lecent Ross, police said Thursday.
Low inflation reflects weakening demand and doesn't inspire confidence about the economic shift from manufacturing to consumption, yet at the same time it should allow Beijing to enact stimulus should it seek to support the economy further .
Influenza neuraminidase: A druggable target for natural products
She then turns back and pecks the man on the cheek, as the crowd erupts in cheers around them.
Will Zimbabwe’s new leader hold — and win — fair elections
The results are based on a survey of 15,870 people across the country in August and September.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
"Protections that promote equality and diversity should not be conditional on someone's sexual orientation," he wrote. "For too long, too many people have had to hide that part of their identity in the workplace."
The role of biosensors in the detection of emerging infectious diseases
Starbucks CEO Howard Schultz
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
The special tokens of appreciation will take place alongside more traditional and somber observances, including the laying of a wreath by President Barack Obama at the Tomb of the Unknown Soldier at Arlington National Cemetery, just across the Potomac River from the nation's capital.
Morgan Slain, CEO of SplashData said: "Seeing passwords like 'adobe123' and 'photoshop' on this list offers a good reminder not to base your password on the name of the website or application you are accessing.
Other commentators, such as Raoul Leering, head of international trade analysis at ING, the Dutch financial group, fear the outlook is bleak even in the short term.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
同时，美国Rapper歌手Eminem被证明是“复出王”，摘得最佳Hip Hop歌手奖。”The Lose Yourself ”的创作者与Hip Hop的新面孔相互竞争，包括Drake, Future, Kendrick Lamar and Post Malone。
Many of his shots hit the front of the rim. Some 3-point attempts were air-balls. He blew one layup that should have been a dunk -- and probably would have been years ago, before all his injuries. And one shot, perhaps the cruelest of all, became lodged where the rim and backboard meet. An opposing player had to help pry it loose.
Mr. Corso restructured Mr. Carell’s nose, giving it a hook. He also shaved his hairline back and gave him more of a forehead.
That growth in the value of inbound shipments came despite a strengthening dollar that drove up costs for importers. Import growth valued in local currency terms reflected that relative weakness with a rise of 13 per cent in November.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
Meanwhile, a salesman from online travel company Tuniu Corp told the Financial Times that it had on Friday “removed all tours to South Korea due to the Thaad issue”. A search for South Korean tours on the website returns the message: “Sorry, we have not found a relevant product.”
According to the report, some lenders have been using the platform to offer female college students high-interest loans on the condition that the borrowers hand over nude photos of themselves holding their ID cards as collateral.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
China's economic performance in the past few years should suffice to put predictions of a hard landing to a full stop. China's economy will continue to enjoy medium-high growth and be upgraded to higher levels
Rather than strangling the doctor (difficult, due to his injury) Jalava took the corny line as inspiration. He decided to go ahead and actually build a prosthetic finger that contains two gigabytes of digital storage. He can now jack his finger into a computer just by peeling back the nail to expose the USB plug. He can also remove the entire finger at any time and hand it to a friend to use.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Spending on medicines in "pharmergingmarkets" will rise more than 50 percent over the next five years, ThePharma Letter said, citing IMS.
FlightAware, well known among travelers for its flight tracking app, calculated arrival delays for 18 major and regional U.S. airlines over the Thanksgiving and winter holiday (Christmas through New Year’s) travel periods, as defined by the Transportation Department, from 2010 through 2012.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
When faced with competition, they may focus less on winning or losing than their Type A counterparts, and more on enjoying the game regardless of winning or losing.
For parents, it is always a struggle to carry their children all day long, especially when they’re getting bigger and heavier.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
政府部门的数据显示，无论在销售额和销售量上看，今年上半年香港房地产销售较去年同期下降了近40%。香港差饷物业估价署(Rating and Valuation Department)本月发布的一项指数表明，商业地产受到的冲击尤为严重，今年5月价格较去年同期下降了5.7%。
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
It is not yet known who will look after Choupette after Lagerfeld's death.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
A member of staff at the Yizheng Museum told MailOnline that the bronze item had been found inside the tomb of an aristocrat in the West Han Dynasty (206 BC–8 AD) the first part of the Han Dynasty.
At the forum, tech entrepreneurs also shared their views on virtual reality, which they said will be the most important computing platform over the next five to 10 years.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Total migrant worker earnings are estimated to be $3 trillion annually, of which approximately 85 percent remains in the host countries. The money migrants send home averages less than one percent of their host country's gross domestic product, IFAD said.
Information technology was the third largest sector with 18 brands shortlisted. The total value of listed IT brands accounted for 22.5 percent of the list. Average value increased 10 percent. Beijing is the preferred headquarters location for the IT sector, and 12 listed IT brands set their headquarters there.
Actors Leonardo DiCaprio and Lady Gaga have led the winners at this year's Golden Globe awards.
This research involves a large longitudinal study of emotion in interactions within married couples.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
In a vote by Sina Weibo，China's Twitter-like website, 58.5 percent of people "liked" the ink painting version of the monkey, only 14.4 percent like the front view of the 3D version, while 12.5 percent want to "change its clothes", supposedly meaning they don't like the colors.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
With a bit of help from Charles Dickens, let’s take a look back at the year in which almost nothing worked:
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
“温总理的讲话重点提到了经济和社会发展。中国政府为实现建设繁荣社会这一目标付出了巨大的努力。”Irene Giner-Reichl, Austrian ambassador
Do your customers trust you? Do they know what you do with their data and are they happy with it? This will be a major issue not just for the N.S.A., Microsoft and Google. Nor will Google Glass be the only product to provoke debate. Trust reduces the cost of doing business and those who don't build relationships of trust with their partners, suppliers and customers will feel the pinch.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Metals cases made up a record 46 per cent of the 233 anti-dumping actions brought worldwide in 2015, with the steel industry accounting for almost all of the metals complaints.
Unlicensed drivers who engage in the services will face a fine ranging from 10 thousand yuan ($1,500) to 30 thousand yuan ($4,500).
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
It's quite an odd question, because Ireally wanted to start writing when I read lots of Stephen King stories. Hisstories were quite astonishing and interesting.
"The guy must have weighted the pros and cons of the situation: he had a great chance to survive a stranded elevator, but would have been doomed if he left homework undone," joked @Zealshifang.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
For many Western whites, opportunities for achieved identity — the top of the hill — seem unattainable. So their ascribed identity — their whiteness — feels more important than ever.
It's real easy for us to sit up here and tell teams that they need to go out there and lose a bunch of games. We're not the ones on the hook for ticket sales and advertisers.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
泰勒·斯威夫特(Taylor Swift)，《空白空间》(Blank Space)， Big Machine
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Barack Obama went on the offensive over foreign policy in the third and final presidential debate, repeatedly accusing Mitt Romney of flip-flopping on major international issues but failing to deliver a killer blow to his opponent's resurgent campaign.
10. Knighted Penguin
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Landing a superstar like Cousins for pennies on the dollar won't singlehandedly help the Pelicans carve out a larger slice of the sports landscape in New Orleans, but it's an excellent first step.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
A private reading on China's manufacturing sector suggests the slowdown continued last month but that conditions had not worsened as much as in October. The Caixin-sponsored preliminary manufacturing PMI was 48.6 in November, versus expectations of 48.3. It had been 48.3 in October.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
不过，在长达四小时的马拉松般的颁奖典礼中，《月光男孩》所获奖项一度与《爱乐之城》并驾齐驱。巴里?詹金斯（Barry Jenkins，文首图中）和塔雷尔?阿尔文?麦克拉尼（Tarell Alvin McCraney，文首图右）获得了最佳改编剧本奖。马赫沙拉?阿里(Mahershala Ali)获得最佳男配角奖，这是美国穆斯林男演员首位获得奥斯卡奖。
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Warren Buffett reclaimed the No. 2 spot on the list for the first time since 2014, with a net worth of $75.6 billion, up from $60.8 billion in 2016.
The Disaster Artist is part buddy movie, part show-business fable, and part behind-the-scenes DVD featurette.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
But a quick look at the changing skyline betrays a frustrating reality: Those shiny new towers have failed to deliver the type of housing most New Yorkers can afford. “There is a disconnect between what we’re building and what we need to build,” said Jonathan J. Miller, the president of the appraisal firm Miller Samuel. “2015 is going to be more of that.”
Will the Democrats take back the majority in the midterm election in the US House of Representatives
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Meanwhile, figures such as Wang Jianlin, China’s richest man, have raised concerns about Chinese state-owned enterprises’ investments in Europe, arguing that they lack international management standards.
Mr Trump is almost a textbook demagogue.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
But shipments to other destinations fared far worse, particularly those to re-exporter Hong Kong, which saw the dollar value of exports from China contract 26.3 per cent year on year to $33.84bn. Shipments to EU countries also fell 4.7 per cent to $33.5bn, while those to Japan dropped 5.5 per cent to $11.27bn.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Well, that’s it, kids: we’re heading home. Chinese shares are down 7 per cent, and thanks to the newly-instituted market circuit breakers, that means the market shuts.
Anti-HIV drug repurposing against SARS-CoV-2
It set minimum prices too high for commodities including cotton, sugar and corn, and as those prices diverged from the market prices, authorities encouraged excessive production as well as strong import flows.
Length-scale dependence of protein hydration-shell density
THE EFFECT OF RAPID CHANGE
Over at Huffington Post Mark Gongloff warns: That 'dramatic downgrade of U.S. economic growth in the first quarter revealed the economy's lingering weakness, exposed the folly of Washington's austerity obsession and slapped the Federal Reserve's newfound optimism right in the face.' And with politics deteriorating, it'll get worse.
Gov. Ricardo Rossello, 37, proposed several measures aimed at alleviating the crisis shortly after he was sworn in at midnight. Among them is a proposal to hold a referendum that would ask voters whether they prefer statehood or independence. Many have argued that Puerto Rico’s political status has contributed to its decade-long crisis that has prompted more than 200,000 people to flee to the U.S. mainland in recent years.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
An ancient Egyptian amulet was uncovered in Jerusalem by a young girl taking part in a family dig in the capital.
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在这场充满政治色彩的颁奖典礼——唐纳德?特朗普(Donald Trump)屡次成为主持人吉米?基梅尔(Jimmy Kimmel)打趣的对象——的末尾，沃伦?比蒂(Warren Beatty)和费?唐纳薇(Faye Dunaway)宣布《爱乐之城》赢得此奖项。然而，就在这部达米安?沙泽勒(Damien Chazelle)编导的现代音乐片的制作人员和演员登上舞台、激动地发表致谢演说时，他们却被告知《月光男孩》才是真正的获奖者。