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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

在这个被大型地产开发商主宰的市场,结构性挑战通常成为抑制欧美大型资产管理公司的因素。
其实,中国经济增速放缓至8%左右,对中国乃至世界都是一件好事。更具环境可持续性、更加公平的局面,将缓解社会忧虑,而更高的消费将缓解全球贸易紧张。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

"Everywhere I go business owners are seeing an increase in demand," said Gus Faucher, senior economist at PNC Financial Services. "Businesses will have to raise wages to attract or maintain workers."
苹果公司和中国移动之间的协议尘埃落定之后,有关苹果下一款重大产品发布的供应链传言又开始浮现。Digitimes报道称,据“上游供应链的消息”,苹果公司正酝酿在明年5月发布一款5英寸屏幕的iPhone 6“平板手机”,在明年10月发布一款大尺寸平板电脑。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

n. 锦标赛,冠军,拥护

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Purchase products like magazine racks, shelves, and desk organizers that will keep your supplies and resources in order and close-at-hand. We love the File File, $24.95, at CB2.com (pictured above).

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

Paul was a pretty undersized guard back in high school, which is probably why he's developed such a "me against the world" mentality. CP3 is one of the grittiest and toughest players in the NBA, and he has to be because he sure isn't one of the biggest.
The artefact which has a flat base was found inside an ancient tomb in the Xuyi County in western Jiangsu in 2009. It has been kept at the Nanjing Museum the capital of Jiangsu Province.
以丹麦为例,如今,88%的丹麦人口都是白人——这样的多数地位很难动摇。但在1980年,也就是上一代人的时候,丹麦有97%的人口是白人。反移民的丹麦人民党(Danish People’s Party)现在是丹麦议会中的第二大党。在德国,从2011年到2015年间,非本土出生人口激增了大约75%,反移民的民粹政党德国另类选择党(Alternative for Germany)如今获得了破纪录的支持率。
她称自己在成为歌手前本来是想当演员的,不过她的音乐事业先获得了成功。她还说“我感觉自己就像电影《月色撩人》中的雪儿。这是我人生中最精彩的时刻之一。”

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
From the themed collection: 2016年LED产业现微增长趋势
Perspective

Trends and targets in antiviral phototherapy

In 2008, China's government added an entry to the list of conditions classified as mental illnesses: "Internet addiction." According to numerous reports in state-run media, China's young people were spending too much time in Internet cafes, ignoring family or work to play online games into the wee hours, sometimes neglecting to eat, drink, or sleep, and endangering their own health.
Bottoms Up is the revolutionary new way to serve beer. The Bottoms Up system saves time, eliminates waste and awes customers!
Nothing else matters, not even basic astronomy.
时间:2010-01-29 编辑:vicki

Graphical abstract: Trends and targets in antiviral phototherapy
From the themed collection: 新华社:稳健运行 底气更足
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

Lighting is key when it comes to getting work done. Instead of investing in your typical, boring college dorm room desk lamp, pick something with a prettier design. Check out vintage stores for one-of-a-kind table lamps or keep it cheap with the Tiffany Table Lamp, $99.99, at Target.com.

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

NeXT 电脑公司总裁兼CEO史蒂夫乔布斯在向公众展示他的新一代NeXT 工作站(此时乔布斯已经离开苹果创办了皮克斯动画和NeXT 电脑公司),1990年9月18日,旧金山

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

一位来自美国佛罗里达州的少女引起了世人的惊叹,因为她长得酷肖迪士尼动画电影《冰雪奇缘》中的艾丽莎女王。
There was no indication of the identity of the kidnappers or their motive.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

The most popular surgical procedures include double eyelid surgery - which reduces excess skin in the upper eyelid to make the eyes appear bigger, lipoplasty - which uses high-frequency sound waves to eliminate fat - and nose jobs.
HOW MUCH: $2,050,000

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

Morgan Stanley CEO James Gorman will do an about-face on the bank's 'lower risk' corporate strategy.
The continued, albeit slower growth in prices tracks with recent data showing real estate investment ticked upward in October and sales had registered barely any negative impact from the new restrictions.

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

这一点,在他首次公开自己的性取向时表现得再突出不过了。
['b?d?it]
On Saturday night they sang Stars from Les Miserables, the song performed the character Javert in the long-running musical.
We had everything before us, we had nothing before us…

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

专业一点

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
From the themed collection: 家居建材市场步入多事之秋
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

Until Dawn
反对:可以把这部电影当作一部演技在线的影片,而不是一部真正伟大的作品吗?

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

Maddie has now appeared in three of Sia's videos - Chandelier, Elastic Heart and Big Girls Cry.

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

At least two Harvard professors, however, questioned the decision to withdraw the offers. Alan Dershowitz, an emeritus professor at Harvard Law School, told the Guardian that losing admission to Harvard was a "draconian punishment" for "very bad taste jokes that students were sending to each other".

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

Two arrests have been made in connection to the shooting death of 14-year-old Lecent Ross, police said Thursday.
Low inflation reflects weakening demand and doesn't inspire confidence about the economic shift from manufacturing to consumption, yet at the same time it should allow Beijing to enact stimulus should it seek to support the economy further .
10. Copyscape
FlightAware以航班跟踪应用程序而为旅行者所熟知,从2010年到2012年,这家网站按照美国交通部的规定,统计了感恩节和冬季假期(圣诞节至新年)旅行期间美国18家大航空公司和地区航空公司的航班延误情况。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

据《每日经济新闻》网报道,经过一项最新调查显示,经济和金融类院校毕业生最有'钱'途。国内5大财经类高校毕业生的平均月薪在1万元以上。
She then turns back and pecks the man on the cheek, as the crowd erupts in cheers around them.
Epic Games在网站Kotaku上发表的一份声明中则指出,提起法律诉讼的原因是罗杰斯在一个YouTube视频的可移除标签上写下了涉及DMCA的反诉内容,这段视频展示并推广了《堡垒之夜》外挂软件。
Will Zimbabwe’s new leader hold — and win — fair elections
The results are based on a survey of 15,870 people across the country in August and September.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

这就真相了,我同意。
"Protections that promote equality and diversity should not be conditional on someone's sexual orientation," he wrote. "For too long, too many people have had to hide that part of their identity in the workplace."

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

Starbucks CEO Howard Schultz

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

单词channel 联想记忆:

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

The special tokens of appreciation will take place alongside more traditional and somber observances, including the laying of a wreath by President Barack Obama at the Tomb of the Unknown Soldier at Arlington National Cemetery, just across the Potomac River from the nation's capital.
马特达蒙凭借他在《火星救援》中扮演的被困宇航员一角而荣获喜剧类最佳男主角奖项。
Morgan Slain, CEO of SplashData said: "Seeing passwords like 'adobe123' and 'photoshop' on this list offers a good reminder not to base your password on the name of the website or application you are accessing.
Other commentators, such as Raoul Leering, head of international trade analysis at ING, the Dutch financial group, fear the outlook is bleak even in the short term.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

同时,美国Rapper歌手Eminem被证明是“复出王”,摘得最佳Hip Hop歌手奖。”The Lose Yourself ”的创作者与Hip Hop的新面孔相互竞争,包括Drake, Future, Kendrick Lamar and Post Malone。
Many of his shots hit the front of the rim. Some 3-point attempts were air-balls. He blew one layup that should have been a dunk -- and probably would have been years ago, before all his injuries. And one shot, perhaps the cruelest of all, became lodged where the rim and backboard meet. An opposing player had to help pry it loose.
Mr. Corso restructured Mr. Carell’s nose, giving it a hook. He also shaved his hairline back and gave him more of a forehead.
That growth in the value of inbound shipments came despite a strengthening dollar that drove up costs for importers. Import growth valued in local currency terms reflected that relative weakness with a rise of 13 per cent in November.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

3.4 以创新引领实体经济转型升级
自这份年度榜单编制之初,“password”就占据了“最常用密码”的榜首位置。而在2013年榜单中,“password” 排名下滑到了第二位。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

单词conduct 联想记忆:
Meanwhile, a salesman from online travel company Tuniu Corp told the Financial Times that it had on Friday “removed all tours to South Korea due to the Thaad issue”. A search for South Korean tours on the website returns the message: “Sorry, we have not found a relevant product.”
单词protection 联想记忆:
v. 引导,指挥,管理
According to the report, some lenders have been using the platform to offer female college students high-interest loans on the condition that the borrowers hand over nude photos of themselves holding their ID cards as collateral.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

他拿出教材,开始做起了家庭作业。
China's economic performance in the past few years should suffice to put predictions of a hard landing to a full stop. China's economy will continue to enjoy medium-high growth and be upgraded to higher levels
Rather than strangling the doctor (difficult, due to his injury) Jalava took the corny line as inspiration. He decided to go ahead and actually build a prosthetic finger that contains two gigabytes of digital storage. He can now jack his finger into a computer just by peeling back the nail to expose the USB plug. He can also remove the entire finger at any time and hand it to a friend to use.

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

Spending on medicines in "pharmergingmarkets" will rise more than 50 percent over the next five years, ThePharma Letter said, citing IMS.
FlightAware, well known among travelers for its flight tracking app, calculated arrival delays for 18 major and regional U.S. airlines over the Thanksgiving and winter holiday (Christmas through New Year’s) travel periods, as defined by the Transportation Department, from 2010 through 2012.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

charitable
When faced with competition, they may focus less on winning or losing than their Type A counterparts, and more on enjoying the game regardless of winning or losing.
For parents, it is always a struggle to carry their children all day long, especially when they’re getting bigger and heavier.

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

平板电脑的病毒出现。
productive
circulate

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

政府部门的数据显示,无论在销售额和销售量上看,今年上半年香港房地产销售较去年同期下降了近40%。香港差饷物业估价署(Rating and Valuation Department)本月发布的一项指数表明,商业地产受到的冲击尤为严重,今年5月价格较去年同期下降了5.7%。

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

It is not yet known who will look after Choupette after Lagerfeld's death.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
From the themed collection: 水性漆的热度,比预期来的更快!
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

A member of staff at the Yizheng Museum told MailOnline that the bronze item had been found inside the tomb of an aristocrat in the West Han Dynasty (206 BC–8 AD) the first part of the Han Dynasty.
At the forum, tech entrepreneurs also shared their views on virtual reality, which they said will be the most important computing platform over the next five to 10 years.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

Total migrant worker earnings are estimated to be $3 trillion annually, of which approximately 85 percent remains in the host countries. The money migrants send home averages less than one percent of their host country's gross domestic product, IFAD said.
Information technology was the third largest sector with 18 brands shortlisted. The total value of listed IT brands accounted for 22.5 percent of the list. Average value increased 10 percent. Beijing is the preferred headquarters location for the IT sector, and 12 listed IT brands set their headquarters there.
Actors Leonardo DiCaprio and Lady Gaga have led the winners at this year's Golden Globe awards.
This research involves a large longitudinal study of emotion in interactions within married couples.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

护符距今已有3200年的历史,上面还刻有“图特摩斯三世”法老的名字。他于公元前1504至公元前1450年在位统治。
In a vote by Sina Weibo,China's Twitter-like website, 58.5 percent of people "liked" the ink painting version of the monkey, only 14.4 percent like the front view of the 3D version, while 12.5 percent want to "change its clothes", supposedly meaning they don't like the colors.

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

adj. 特指的;指定的
9.Touchscreens

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
From the themed collection: 定制家具难称心 应细签合同
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

With a bit of help from Charles Dickens, let’s take a look back at the year in which almost nothing worked:

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

“温总理的讲话重点提到了经济和社会发展。中国政府为实现建设繁荣社会这一目标付出了巨大的努力。”Irene Giner-Reichl, Austrian ambassador
科学家们在赋予人体器官原本能力方面投入很深,但是为何要仅限于此呢?
Do your customers trust you? Do they know what you do with their data and are they happy with it? This will be a major issue not just for the N.S.A., Microsoft and Google. Nor will Google Glass be the only product to provoke debate. Trust reduces the cost of doing business and those who don't build relationships of trust with their partners, suppliers and customers will feel the pinch.
政治建军、改革强军、依法治军

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

Metals cases made up a record 46 per cent of the 233 anti-dumping actions brought worldwide in 2015, with the steel industry accounting for almost all of the metals complaints.
Unlicensed drivers who engage in the services will face a fine ranging from 10 thousand yuan ($1,500) to 30 thousand yuan ($4,500).

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

It's quite an odd question, because Ireally wanted to start writing when I read lots of Stephen King stories. Hisstories were quite astonishing and interesting.
时间:2009-10-22 编辑:vicki
"The guy must have weighted the pros and cons of the situation: he had a great chance to survive a stranded elevator, but would have been doomed if he left homework undone," joked @Zealshifang.

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

智联招聘最近的一份调查报告显示,在参与调查的2016届应届毕业生中,毕业后选择创业的比例为仅仅只有3.1%,而2015年的比例是6.3%。
国家大学排行榜单数量从去年的38份上升到42份。新加入的榜单包括阿根廷、墨西哥、巴基斯坦和罗马尼亚大学排行榜。
在周五晚上,金州勇士队以106比94击败了芝加哥公牛队,将战绩提升为14胜0负。库里本场比赛拿下27分,而卫冕冠军也距离NBA历史最佳开局纪录只有一场之遥。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
From the themed collection: 集成定制改写未来家居
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

For many Western whites, opportunities for achieved identity — the top of the hill — seem unattainable. So their ascribed identity — their whiteness — feels more important than ever.
It's real easy for us to sit up here and tell teams that they need to go out there and lose a bunch of games. We're not the ones on the hook for ticket sales and advertisers.

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
From the themed collection: 国内钛白粉价格持续下跌
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

1. Technausea.
谎言2:好的,我会尽快开工的!说谎原因:如果我告诉你在做你要求的这件事之前,我还有10件事要做的话,你肯定会抓狂的。
泰勒·斯威夫特(Taylor Swift),《空白空间》(Blank Space), Big Machine

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

倒灌啤酒机是倒啤酒的一种革命性创新方式,节省时间,减少浪费,也令顾客啧啧称奇。
stick

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

Libby把这首歌放在了YouTube频道的评论部分,我把它摘过来了。我将大量的可爱的表述和英式的俚语都用不同颜色区分开了。你能猜出其中的意思吗?“OMG”表带什么意思?
Barack Obama went on the offensive over foreign policy in the third and final presidential debate, repeatedly accusing Mitt Romney of flip-flopping on major international issues but failing to deliver a killer blow to his opponent's resurgent campaign.
10. Knighted Penguin

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

11月17日

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
From the themed collection: 建筑外墙 能“吃”雾霾
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

Landing a superstar like Cousins for pennies on the dollar won't singlehandedly help the Pelicans carve out a larger slice of the sports landscape in New Orleans, but it's an excellent first step.
n. 权力,权威,职权,官方,当局

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

除了你的华生,他会觉得这样的你性感极了!
A private reading on China's manufacturing sector suggests the slowdown continued last month but that conditions had not worsened as much as in October. The Caixin-sponsored preliminary manufacturing PMI was 48.6 in November, versus expectations of 48.3. It had been 48.3 in October.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

《死侍》将于2016年2月12日爆笑上映。 当然,电影中还有不少动作和杀戮场景。
“这个孩子将来会有大成就的——记住我这句话。”

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

城镇新增就业1100万人以上,城镇登记失业率4.5%以内;
不过,在长达四小时的马拉松般的颁奖典礼中,《月光男孩》所获奖项一度与《爱乐之城》并驾齐驱。巴里?詹金斯(Barry Jenkins,文首图中)和塔雷尔?阿尔文?麦克拉尼(Tarell Alvin McCraney,文首图右)获得了最佳改编剧本奖。马赫沙拉?阿里(Mahershala Ali)获得最佳男配角奖,这是美国穆斯林男演员首位获得奥斯卡奖。

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

乔纳森·格雷泽导演的《皮囊之下》讲述的是一位美丽又可怕的外星人的故事,她本身美丽,恐怖而且是个外星人:这是一部完全与众不同的,残暴的色情电影。乔纳森·格雷泽以前导演的优秀作品仅仅只是为这部电影做的局部模糊的铺垫。他的《性感野兽》(2000)是一部令人视觉上满足的,兴奋的,充满智慧的犯罪惊悚片,它超越了那个年代操着方言的悲剧老头的模式。《重生》(2004)有着库布里克式的精致与阴冷,电影中的一些画面,十分出色;它是一部值得奉为经典的电影,但尚未实现。接着十年过去了,对那些电影事业一直无法实现的人,格雷泽似乎成为他们的设计师。(天知道,这种事情总发生在那些有天赋的人身上)。

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

Warren Buffett reclaimed the No. 2 spot on the list for the first time since 2014, with a net worth of $75.6 billion, up from $60.8 billion in 2016.
这个报告没有谈到可能影响患病数量的原因,但是很多人,包括在野党的成员,归咎于政府一味缩减医疗健康成本预算。
想知道2013年的最差工作是哪些吗?报社记者以其令人尴尬的特质,取代伐木工人成为今年的最差工作。
The Disaster Artist is part buddy movie, part show-business fable, and part behind-the-scenes DVD featurette.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
From the themed collection: 北京俩限房价楼盘被立案查处
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

报告显示,去年国内手机总出货量为5.6亿部,同比增长8%。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

另一个会造成失业的常见的习惯就是过度沉溺于社交媒体。有些公司采取了相应的措施来监控或限制员工使用社交媒体。有些公司甚至完全屏蔽掉这些网站。所以注意了花太多的时间在社交媒体或者与工作无关的网站上可能会让你饭碗不保哦!
But a quick look at the changing skyline betrays a frustrating reality: Those shiny new towers have failed to deliver the type of housing most New Yorkers can afford. “There is a disconnect between what we’re building and what we need to build,” said Jonathan J. Miller, the president of the appraisal firm Miller Samuel. “2015 is going to be more of that.”
Will the Democrats take back the majority in the midterm election in the US House of Representatives

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

Meanwhile, figures such as Wang Jianlin, China’s richest man, have raised concerns about Chinese state-owned enterprises’ investments in Europe, arguing that they lack international management standards.
Mr Trump is almost a textbook demagogue.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

But shipments to other destinations fared far worse, particularly those to re-exporter Hong Kong, which saw the dollar value of exports from China contract 26.3 per cent year on year to $33.84bn. Shipments to EU countries also fell 4.7 per cent to $33.5bn, while those to Japan dropped 5.5 per cent to $11.27bn.
这一新数据公布之际,杜特尔特正抵御国内外对其禁毒运动的指责,已有60万名潜在嫌疑人向当局自首。

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
From the themed collection: 温州家具品牌“内冷外热”
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

Well, that’s it, kids: we’re heading home. Chinese shares are down 7 per cent, and thanks to the newly-instituted market circuit breakers, that means the market shuts.

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

It set minimum prices too high for commodities including cotton, sugar and corn, and as those prices diverged from the market prices, authorities encouraged excessive production as well as strong import flows.
[k?n'tinju?s]
但并非所有记者──比如笔者本人──都认同这个最终评估结果。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

源于:repertory(n 仓库),剧目的仓库-全部剧目
THE EFFECT OF RAPID CHANGE
Over at Huffington Post Mark Gongloff warns: That 'dramatic downgrade of U.S. economic growth in the first quarter revealed the economy's lingering weakness, exposed the folly of Washington's austerity obsession and slapped the Federal Reserve's newfound optimism right in the face.' And with politics deteriorating, it'll get worse.
Gov. Ricardo Rossello, 37, proposed several measures aimed at alleviating the crisis shortly after he was sworn in at midnight. Among them is a proposal to hold a referendum that would ask voters whether they prefer statehood or independence. Many have argued that Puerto Rico’s political status has contributed to its decade-long crisis that has prompted more than 200,000 people to flee to the U.S. mainland in recent years.

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

adj. 深思的,体贴的
最佳歌曲:

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

一个问题接着一个问题,从伊朗制裁到从阿富汗撤军,他的位置和政府态度之间的差别不大,但罗姆尼坚持他将更有效地加强美国的力量。
英国门萨首席执行官约翰·斯蒂门尼奇说他为妮诗感到高兴。他说:“我希望她能充分利用好成为门萨会员的机会,结交志趣相投的新朋友,不断挑战自己。加入门萨,就为你打开了一扇大门。门萨是一个会员超过10万人的世界网络,很多会员会成为终生好友。”
An ancient Egyptian amulet was uncovered in Jerusalem by a young girl taking part in a family dig in the capital.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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在这场充满政治色彩的颁奖典礼——唐纳德?特朗普(Donald Trump)屡次成为主持人吉米?基梅尔(Jimmy Kimmel)打趣的对象——的末尾,沃伦?比蒂(Warren Beatty)和费?唐纳薇(Faye Dunaway)宣布《爱乐之城》赢得此奖项。然而,就在这部达米安?沙泽勒(Damien Chazelle)编导的现代音乐片的制作人员和演员登上舞台、激动地发表致谢演说时,他们却被告知《月光男孩》才是真正的获奖者。
[stres]

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